Genetics of Rheumatoid Arthritis Registry

Many genes are thought to contribute to rheumatoid arthritis (RA). Currently only one such gene has been identified. This study will attempt to identify all of the genes that may contribute to RA and determine which specific genetic variations are responsible for the disease.

Description

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study will enroll patients with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated by a study official at his or her doctor’s office or other location convenient for the participant. Participants will have a brief interview and physical exam and a blood sample will be obtained. Disease evaluation will be done at one visit and will include a 28 joint count, joint alignment and mobility score (JAMS), administration of a health assessment questionnaire and other related questionnaires. Physician confirmation of diagnosis will also be included in the disease evaluation.

Status: Recruiting (N/A). Started on October 1st, 2002. Ended on September 1st, 2007.

Enrollment: 3000 subjects

Study Type: Observational

Study Design:

Family-Based
Cross-Sectional

Conditions:

Rheumatoid Arthritis

Interventions:

Eligibility

Inclusion Criteria:

Adult onset RA, RF positive or anti-CCP positive
Diagnosis of RA made between 18 and 60 years old
Both parents alive and willing to participate
Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

Inflammatory bowel disease
Lupus
Psoriatic arthritis

Gender: Both
Mininum Age: 18 Years
Maximum Age: N/A
Healthy Volunteers: No

Resources

Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Authority: United States: Federal Government

Locations

North Shore Long Island Jewish Research Institute
Manhasset
New York
11030
United States

Officials

Peter K. Gregersen, MD (Principal Investigator, North Shore University Hospital)

References

Jawaheer D, Li W, Graham RR, Chen W, Damle A, Xiao X, Monteiro J, Khalili H, Lee A, Lundsten R, Begovich A, Bugawan T, Erlich H, Elder JT, Criswell LA, Seldin MF, Amos CI, Behrens TW, Gregersen PK. Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet. 2002 Sep; 71(3): 585-94. Epub 2002 Aug 09.
PMID: 12181776.
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Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schroeder HW Jr, Bridges SL Jr, Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, Gregersen PK. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet. 2001 Apr; 68(4): 927-36. Epub 2001 Mar 09.
PMID: 11254450.
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Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Etzel C, Damle A, Xiao X, Chen D, Lum RF, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schroeder HW Jr, Bridges SL Jr, Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, Gregersen PK; North American Rheumatoid Arthritis Consortium. Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum. 2003 Apr; 48(4): 906-16.
PMID: 12687532.
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Links

Click here for the North American Rheumatoid Arthritis Consortium Web site (current study data, publications, and registry contact information)

Date Verified: February 1st, 2008
First Received: February 29th, 2008
Last Changed: February 29th, 2008

Information obtained from ClinicalTrials.gov on July 15, 2008. Link to the current ClinicalTrials.gov record.

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