Resveratrol for Patients With Colon Cancer
Resveratrol is purported to possess cancer preventive activity, especially for colon cancer, though its mechanisms of action are not well defined. Resveratrol is found in the skin of grapes and has anti-oxidative and pro-apoptotic effects on cancer cell lines in vitro. The main dietary sources of resveratrol are grapes, grape products, red wine and small amounts in mulberries. A prior report and compelling preliminary data from our laboratory suggest that resveratrol modulates Wnt signaling, a signaling pathway which is activated in over 85% of colon cancers. In this proposal, studies will be performed to define the actions of resveratrol on the Wnt signaling pathway in a clinical trial in which patients with colon cancer will receive treatment with resveratrol and correlative laboratory studies will examine its effects directly on colon cancer and normal colonic mucosa. These studies will provide data on the mechanisms of resveratrol action and provide a foundation for future prevention trials, correlative studies and therapeutic clinical research with this agent.
Status: Recruiting (Phase 1/Phase 2). Started on July 1st, 2005. Ended on December 1st, 2009.
Enrollment: 12 subjects
Study Type: Interventional
Study Design:
- Treatment
- Non-Randomized
- Open Label
- Uncontrolled
- Single Group Assignment
- Efficacy Study
Conditions:
Interventions:
- Drug: Resveratrol
Eligibility
Inclusion Criteria:
Patients diagnosed with colon cancer by colonoscopic biopsy and tissue obtained under UCI04-05.
Patients with a plan for surgical resection at UCIMC within 2-4 weeks of enrollment.
Exclusion Criteria:
•Surgical resection to be performed at a facility other than UCIMC.
- Gender
Both
- Mininum Age
18 Years
- Maximum Age
N/A
- Healthy Volunteers
No
Resources
Source: University of California, Irvine
Authority: United States: Institutional Review Board
Locations
-
Chao Family Comprehensive Cancer Center
Orange
California
92868
United States
Officials
Randall Holcombe, MD (Principal Investigator, Chao Family Comprehensive Cancer Center)
Sponsors
University of California, Irvine (Lead Sponsor)
References
None.
Links
None.
- Date Verified
- March 1st, 2008
- First Received
- March 21st, 2008
- Last Changed
- March 21st, 2008
Information obtained from ClinicalTrials.gov on July 15, 2008. Link to the current ClinicalTrials.gov record.
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