Redox Determinants in Severe Asthma
Hypotheses: 1) Airway pH regulation is abnormal in severe asthma; 2) In severe asthma, there is formation of cytotoxic nitrogen oxides and loss of beneficial nitrogen oxides in the airways
Description
Specific Aim 1:Test hypothesis that airway pH regulation is abnormal in severe asthma.
1a) Determine the effects of systemic corticosteroids on breath pH in children with severe and mild to moderate asthma.
1b) Examine whether breath condensate pH and other biomarkers of oxidant stress can predict clinical outcomes in children with severe and mild to moderate asthma.
1c) Identify whether increased Th1/Th2 cytokine ratio, and abnormalities in airway glutaminase, G-SNO-reductase, VATPase, and carbonic anhydrase are associated with airway pH disturbance in children with severe asthma.
1d) Test whether rhinovirus infections, which reduce airway pH, persist longer or are more frequent in children with severe asthma than in children with mild to moderate asthma.
1e) Examine the relationship between gastroesophageal reflux and proximal airway pH in children with severe asthma and mild to moderate asthma.
Status: Recruiting (N/A). Started on July 1st, 2006. Ended on June 1st, 2008.
Enrollment: 20 subjects
Study Type: Interventional
Study Design:
- Diagnostic
- Open Label
- Single Group Assignment
Conditions:
Interventions:
- Drug: triamcinolone (Kenalog IM)
- Drug: albuterol
- Drug: methacholine PC20
Eligibility
Inclusion Criteria:
At least 6 years old
Asthma diagnosis by physician
Current treatment with an inhaled corticosteroid medication
- Gender
Both
- Mininum Age
6 Years
- Maximum Age
21 Years
- Healthy Volunteers
No
Resources
Source: Emory University
Authority: United States: Institutional Review Board
Locations
-
Emory Childrens Center
Atlanta
Georgia
30322
United States
Officials
None.
Sponsors
Emory University (Lead Sponsor)
The Cleveland Clinic (Collaborator)
References
None.
Links
None.
- Date Verified
- March 1st, 2007
- First Received
- January 9th, 2008
- Last Changed
- January 9th, 2008
Information obtained from ClinicalTrials.gov on July 15, 2008. Link to the current ClinicalTrials.gov record.
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