Pharmacokinetics and Pharmacodynamics of Fructose Following Soft Drink Consumption: Sucrose vs High Fructose Corn Syrup
The purpose of this study is to determine whether sucrose vs high fructose corn syrup from a soft drink results in differences in various metabolic byproducts such as fructose, glucose, serum uric acid, triglyceride and lactate.
Description
Fructose consumption has risen sharply during the past several decades. Since its introduction to the United States in 1967, high fructose corn syrup (HFCS) has overtaken sucrose as the main sweetener in manufactured foods and beverages, and thus, is responsible for the approximately 30% increase in fructose in our diet. Numerous studies have shown that excessive fructose consumption can cause a variety of harmful metabolic effects, suggesting that fructose may partially be responsible for the current epidemic in obesity, hypertension, metabolic syndrome, and diabetes.
This preliminary study will investigate the pharmacokinetics and pharmacodynamics of fructose in a broad population. Specifically, the goal of our research are to compare the impact of the two main sources of dietary fructose, sucrose versus HFCS, on fructose bioavailability and acute metabolic changes by measuring response phenotypes, such as serum uric acid, lactate, and triglyceride levels.
Status: Recruiting (N/A). Started on March 1st, 2008. Ended on March 1st, 2010.
Enrollment: 40 subjects
Study Type: Observational
Study Design:
- Other
- Prospective
Conditions:
Interventions:
- Other: Dr Pepper sweetened with sucrose or high fructose corn syrup
Eligibility
Inclusion Criteria:
adult subjects aged 18 years or older
either gender
any ethnicity
willing to abstain from drinking any alcohol 3 days prior to a study visit
Exclusion Criteria:
history of liver or kidney disease
history of diabetes mellitus or fasting blood glucose ��� 126 mg/dl or random blood glucose ��� 200 mg/dl
currently taking any medication (except oral contraceptives)
consume more than 1 alcoholic drink per day
pregnant or breast-feeding
blood donor in the previous 8 weeks
history of gout
- Gender
Both
- Mininum Age
18 Years
- Maximum Age
N/A
- Healthy Volunteers
Accepts Healthy Volunteers
Resources
Source: University of Florida
Authority: United States: Institutional Review Board
Locations
-
University of Florida, Department of Pharmacy Practice, Center for Pharmacogenomics
Gainesville
Florida
32610
United States
Officials
Julie A Johnson, Pharm.D. (Principal Investigator, University of Florida)
Sponsors
University of Florida (Lead Sponsor)
References
None.
Links
None.
- Date Verified
- February 1st, 2009
- First Received
- February 13th, 2009
- Last Changed
- February 13th, 2009
Information obtained from ClinicalTrials.gov on February 16, 2009. Link to the current ClinicalTrials.gov record.
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